Friday, April 15, 2011

Pharmacists Coffee [PCM] Novartis Discontinues Clinical Trial of Tasigna? + Vacancies [1 Attachment]

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Pharmacists_ coffee magazine
Electronic Edition
Edition No. 401, year 4
April 15, 2011
Today's edition sent to:
23,680 Arabian Pharmacists

Find Valuable attachment
"18 Ways to Plan Your Day"
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Today in Hot pharma news







Medicine of the week


Ranitidine (pronounced /rəˈnɪtɨdiːn/) (trade name Zantac) is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). Ranitidine is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives.

Clinical use:

Certain preparations of ranitidine are available over the counter (OTC) in various countries. In the United States, 75 mg and 150 mg tablets are available OTC. Zantac OTC is manufactured by Boehringer Ingelheim. In Australia, packs containing 7 or 14 doses of the 150 mg tablet are available in supermarkets, small packs of 150 mg and 300 mg tablets are Schedule 2 Pharmacy Medicines. Larger doses and pack sizes still require a prescription.
Outside the United States, ranitidine is combined with bismuth (which acts as a mild antibiotic) as a citrate salt (ranitidine bismuth citrate, Tritec), to treat Helicobacter pylori infections. This combination is usually given with clarithromycin, an antibiotic.
Ranitidine's main role is in treating gastric and duodenal ulcers and gastroesophageal reflux disease. It is also used to treat pediatric reflux, where it is preferred over a PPI, because it does not induce histologically relevant hyperplastic changes in the parietal cells. Liquid formulations are available for administering to children.
Ranitidine can also be co-administered with NSAIDs to reduce the risk of ulceration.
Ranitidine can be administered preoperatively to reduce the risk of aspiration pneumonia. The drug not only increases gastric pH, but also reduces the total output of gastric juice. Ranitidine may have an antiemetic effect when administered preoperatively.
It can be administered IV in intensive care units to critically ill patients (particularly geriatric ones) to reduce the risk of gastric bleeding.
The usual dose of ranitidine is either 150 mg twice a day or 300 mg once every twenty four hours, usually at night. For ulcer treatment, a 300 mg nighttime dose is especialy important - as the increase in gastric/duodenal pH promotes healing overnight when the stomach and duodenum are empty. Conversely, for treating reflux, smaller and more frequent doses are more effective.
Ranitidine used to be administered long term for reflux treatment, sometimes indefinitely. However, PPIs have taken over this role.
In some patients with severe reflux, up to 600 mg of ranitidine can be administered daily, usually in 4 lots of 150 mg. Such a high dose was not unusual in the past, but nowadays a once-a-day PPI is used instead - both for convenience and because they are more effective in raising gastric pH. Patients with Zollinger-Ellison syndrome have been given doses of 6000 mg per day without any harm.
Ranitidine's main side effects are confusion and depression, although these are very rare and usually only seen in geriatric patients.

History and development:

Ranitidine was developed by Glaxo in an effort to match the success of Smith, Kline & French (prior to the merger of the two companies into GlaxoSmithKline) with the first histamine H2-receptor antagonist cimetidine. Ranitidine was the result of a rational drug-design process using what was by then a fairly refined model of the histamine H2-receptor and quantitative structure-activity relationships (QSAR).
Glaxo refined the model further by replacing the imidazole-ring of cimetidine with a furan-ring with a nitrogen-containing substituent, and in doing so developed ranitidine. Ranitidine was found to have a far-improved tolerability profile (i.e. fewer adverse drug reactions), longer-lasting action, and ten times the activity of cimetidine. Ranitidine has 10% the affinity that cimetidine has to CYP450 so it causes fewer side effects, but other H2 blockers famotidine and nizatidine have no CYP450 significant interactions.[1]
Ranitidine was introduced in 1981 and was the world's biggest-selling prescription drug by 1988. It has since largely been superseded by the even more effective proton pump inhibitors, with omeprazole becoming the biggest-selling drug for many years. When omeprazole and ranitidine were compared in a study of 144 people with severe inflammation and erosions or ulcers of the esophagus, 85% to those treated with omeprazole healed within eight weeks, compared to 50% of those given ranitidine. In addition, the omeprazole group reported earlier relief of heart burn symptoms.


















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Fresh Graduates Medical rep. – KSA

Medical Saudi Company have a different agencies in middle east especially Gulf region , The company Working scope is governmental hospitals to promote and distribute unique medical devices . Seeking a medical rep. with following requirements :

• Fresh Graduated Only .

• Ability to travel domestic and international .

• Transferable Iqama .

• Driving license .

• Resident in Jeddah .

Please send your C.V with recent photo within 1 week on :




Medical Rep. – Institution / Eastern Province

A fast growing pharmaceutical organization is willing to recruit a medical representative in the Eastern Province – Saudi Arabia, with the following criteria;

1. Pharmacist

2. Age below 28 years old

3. Fluent English language

4. Transferable Saudi Iqama

Candidates are requested to send their CV's via e-Mail to:




Medical Representative for Madina

Well established pharmaceutical company

urgent hiring male med rep in Madina

experience not less than one year

age must below  25 years

please send your cv on


Fax no : 048475989



Multinational pharmaceutical company in KSA

A multinational  pharmaceutical company in Saudi Arabia is look to recruit

Medical Representatives with the following criteria:

*Bachelor Degree in Pharmacy,Veterinary

* Experience (not less than 2 year)prefered in central Area-riyadh

*Age not more than 29 years

*Transferable Saudi Iqama is a Must

Please send your CV on this E-mail




Medical Representatives in Jeddah and Riyadh

A Distinguished Establishment Which Represents Five Reputable Manufacturers is looking to Recruit
Medical Representatives in Jeddah and Riyadh with the following criteria:
1-Bachelor Degree in Pharmacy or Veterinary Medicine
2- Experience (not less than 1year) Prefer in Jeddah or Riyadh
3- Age Not More Than 30 Years
4-Transferable Saudi Iqama is a Must
5-Have Saudi Valid Driving license
6-Excellent Command of English Language
7-Available For Immediate Hiring

Interested Applicants Should Submit Their Resumes to E-Mail:




Pharmacist Required

Alsalsabil Pharmacy at (jeddah KSA) needs a qualified pharmacist to work on loan

From 2 pm till 1 am (11 hours )

Please contact me : 0546432348

Dr. Hatem Desouky



Medical rep. in KHOBAR – Medical supplies -

Well organized  medical co. specialized in medical supplies required sales & medicals rep. as follows:
1  At least 1 years experience  in Eastern area

2. Experience in medical supplies is a MUST.
3- Pharmacist, veterinarian or science
4 . age not more than 28
5. Transferable Iqama is a MUST
6- Available for immediate hiring .

Kindly send your c.v. to :




Medical Rep. – Eastern Province

A fast growing pharmaceutical organization is willing to recruit a medical representative in the Eastern Province – Saudi Arabia, with the following criteria;

1. Pharmacist

2. Age below 28 years old

3. Fluent English language

4. Transferable Saudi Iqama

Candidates are requested to send their CV's via e-Mail to




M.Rs In Saudi Arabia (Jeddah)

Leading pharmaceutical company is look to recruit

Medical Representatives with the following criteria:

*Bachelor Degree in Pharmacy,Veterinary or science

* Experience (not less than 1 year) Prefer in Western Area

*Age not more than 28 years

*Transferable Saudi Iqama is a Must

*Holding Saudi Valid Driving license

* Available for immediate hiring

Candidates fulfilling the above criteria should send your C.V. to the following mail


Fax NO.: 026651037



Pharmacy director

Pharmacist with experience required in Jeddah

10 hours/day, Friday is off

Excellent salaries

Tel:  0566811959



Medical Reps – Riyadh

leading international company

is seeking  for Reps with the following criteria:

-Male -Based in Riyadh – vet or pharmacist or science- Holding Saudi Valid Driving license- Good command of English language - Excellent Communications skills -

Interested candidates can send their  CV's with recent photo to


Fax: 02 671 8281



Male M.R – Jeddah KSA

New Pharmaceutical Company in Saudi Arabia requires male medical Reps based in JEDDAH.

Job Qualifications :
- Pharmacist, Vet. , Science .
- Previous experience .
- Age below 27 Years is a must.

Interested candidate should send his CV with a recent photo to:



FAX: 026651037



Regulatory Affairs Specialist-Saudi Nationality

Regulatory Affairs Specialist / KSA

A leading Medical / Pharmaceutical company is searching for a regulatory affairs specialist to handle the products registration in Saudi Arabia & to deal with the new regulation of the Saudi FDA

The following basic qualifications are required:

University degree (Male / Female), Saudi Nationality , 2 years experience in similar position in KSA , English / Arabic speaking , French speaking will be an addition, Excellent computer skills

Please send your CV to


All CVs will be treated highly confidential and we will consider potential candidates only









Egypt to KSA


+ Add a vacancy 



Pharmacists for KSA

Group pharmacies in Saudi Arabia requires pharmacists

2000 - 2010 graduates

Excellent salaries & commission

Please send your CV to:


Mob: 0114545673

Fax: 02-22728992





+ Add a vacancy 








Egypt to Egypt

 + Add a vacancy




Eli Lilly

Is seeking to recruit candidates for the following positions in its expanding manufacturing operations at 6th of October city:

1-    Quality control laboratory administrator (Job Ref. Mfg/01)

·         3 years prior experience in an administrative post

·         Working in a GMP regulated industry is a plus

2-    quality control laboratory microbiologist (Job Ref. Mfg/02)

·         a minimum of bachelor degree in pharmaceutical science

·         have at least 1 year prior experience in a sterile manufacturing

·         have sufficient knowledge of guidelines and microbiological testing practice

3-    quality assurance representative (Job Ref. Mfg/03)

·         minimum of bachelor degree in pharmaceutical science

·         have at least 2 year experience in QA related activities in sterile manufacturing area and GMP compliance

·         have sufficient knowledge of guideline & GMP regulations

4-    admin assistant & technical writer (Job Ref. Mfg/04)

·         have at least 2 years experience as technical writer (working in a GMP regulated industry is a plus)

·         have sufficient knowledge about good documentation practices

·         position is a temp for one year and three months

all above jobs must possess:

*a university degree with very good command of english and microsoft Office skills

Excellent communication, organizational, and interpersonal skills

Preferable demonstrate progressive responsible experience in the pharmaceutical manufacturing industry and strong familiarity with cGMP's

Please send your CV with recent photo & job Ref. within 2 weeks to:

B.O Box Al-Ahram [2011/26]



or Fax: 02-38341186



Urgently Required Medical Reps

Medical Reps are urgently required for a very well established company.

Matarya & Helwan & Port-Said.

Only hard working ambitious with spirit of success candidates are most welcome.

Pharmacists , Vets. and Science Graduates.

Excellent Package & Transportation & Car policy apply after 6 months.

Send you C.V with a subject of your area to :




Health expert company

Health expert Pharmaceutical company is partner with GNP in line cardiology and neurology  is seeking  Medical Reps.

for all government except upper Egypt with very attractive salary,car allowance ,and very good incentive scheme

the right candidate should be:

a-Pharmacist,Vet or science graduate

b-experience or fresh graduates are welcomed

Kindly send your CV with a recent photo within one week Mentioning area of residence in subject to:




Multi_Pharma Pharmaceutical Co.

Alexandria Scientific office

requires Medical rep (vet ,science and pharmacist)

only who live in Alexandria are invited to apply for the vacancy by sending CV to:


for more info call 0106344807

(Dr Abdallah Hassan DM Derma line) Alexandria scientific Office



Multinational pharmaceutical company

Multinational pharmaceutical company is looking for the following Positions :
1) Product manager(Ref.PM)

2) Regulatory specialist (Ref.RS)

3) Medical specialist (Ref.MS)

4) Executive secretary (Ref.ES)

5) Accountant (Ref.AC)

Minimum 2 years experience in the same field for each position.

For the selected candidates, we offer a superb working environment and a challenging atmosphere.

please send your CV with recent photo to the below email within one week.


Kindly mention the job Reference in the subject field.



Hospital Line Medical Rep.

Multinational pharmaceutical company

is seeking for Part-time and Full-time

Hospital line Medical Rep.

Resident in Menoufia or Mansoura

Fresh or experienced, Hard worker, enthusiastic & self motivated.

Please send an updated C.V. with a recent photo to the following e-mail:




SIGMA – Vacancy in Alexandria

SIGMA Pharmaceutical Industries is a leading pharmaceutical company in Egypt

Is seeking highly qualified candidates for urgent hiring in Alexandria to fulfil the following position

Institutional Medical Representatives

with the following criteria:

- Male or female, pharmacist, age not more than 28 years,

- 2 Years experience, resident in Alexandria

- Excellent command of English language

- Available for immediate hiring

We offer a very competitive package plus facilities

Candidates fulfilling the above criteria should send your C.V. to the following e-mail


Mob: 0123922028



Urgent for Multipharma

1- medical rep,fresh or experienced ,resident in guiza,haram,faesal,ma3adie,manel,mohandseen or dokkie,for attractive salary,car 4 years to be own,health insurance….

2-district manager,3 years senior in multinational company or  already has supervisor or district  title,resident in guiza,haram,faesal,ma3adie,manel,mohandseen or dokkie,for attractive salary,car 4 years to be own,health insurance….

if interested send your cv with recent photo to:





Medical Representative Based in

Upper Egypt

Male or Female

Experienced or fresh graduate

Vet and Pharmacist are preferred

Owning a car will be an assist

We offer a competitive package with excellent carer path and a car policy

Send your CV to the following e-mail address





Medical Representative Based in :

Mansoura   (Ref : Mans )

Damita    (Ref : Dam )

Male or Female

Experienced or fresh graduate

Vet and Pharmacist are preferred

Owning  a car will be an assist

We offer a competitive package with excellent carer path and a car policy

Send your CV with the Ref Code in the Subject area to the following e-mail address




Full time Medical Rep. for Maadi, Helwan

Local fast growing pharmaceutical company offering real attractive package.
Selected candidate should be Pharmacist or Vet only , fresh graduate or 1-2 years experience .
Those interested candidates please send your CV to:


within one week.



Delta Bio International Pharmaceutical Co.

For immediate hiring

We need med.reps. (pharmacist-vet-science) for the following area:
Alexandria (Center-west)

send your c.v to


training soon
with best wishes for all



Lanton Pharma

Medical Representative – Giza Area


1- Fresh or 1-2  year experience

2-Vet, physiotherapy   or science

3-Age does not exceed 27 (male or female)

4- with excellent package ,to apply

full and part time                           ref.        full time  ft.

part time  pt

please send CV. with recent photo to




Medical Representative

KARISMAL is an newly progressing Egyptian pharmaceutical company

Requires medical reps either pharmacist – vit or science for maadi  & nasr city

Please send your c.v with recent photo to following e-mail:


or contact: 0168816792



Liptis Pharmaceuticals – Suez & South Sina

-Med. rep.
_Only vet. or pharmacist .
_Male or Female
_Must BE Resident in SUEZ only
_have driving license


_apply c.v. 10 days to





Abbott Nutrition International

Abbott Nutrition International is a world wide leader in pediatric & medical nutritional, seeking to hire medical representative in Alex area with the following criteria:

Must be FEMALE resident in Alexandria city

Pharmacist or veterinarian or science biology

Experience is not a must

good command of English language & computer skills

Presentable & self motivated

Right candidates should send their C.V.s & must indicate in the mail title name & area, to the following e-mail




International Trading Office

A well established pharmaceutical company, seeking for highly qualified

candidates for:

1- Medical Rep (Ref. M.R)

* Pharmacist, Vet,  Science

* Talented & hard worker

2- Secretary (Ref. S)

* Female

*English & computer is a must

To join our team send your C.V to:




Abbott Nutrition International

Is seeking to hire FEMALE medical representative resident in CAIRO, GIZA & ALEX

candidates should be:


Fresh graduated or with experience

send your C.V.s & you must indicate on the mail title NAME & GOVERNORATE to:




dBk Pharma

Well established industrial pharmaceutical company

dBk pharma


Due to our expansion we need the following position

-Medical Representatives         Ref: (MSR)

For Cairo (All Governorates)

Giza (All Governorates)


-Pharmacist or Vet.

-previous experience in pharmaceutical company

Or fresh graduated.

- Good English and computer skills.

-  Ambitious, dynamic, self motivated

And High ability to learn

We offer

Healthy Workplace &Career Development. Strategy

-Attractive salary and benefits.

Kindly send your CV With recent photo to email:




Pharmacy in Abbas Al-Akkad

1-    Female pharmacist for morning shift

2-    Pharmacist for evening shift

3-    Pharmacist for night shift

4-    Assistants

5-    Delivery

Please send your CV to:




El-Tarshouby pharmacies

Requires pharmacists

In Mansoura & Mahala

Salary depends on experience

Please send your CV to:

or call: 01999 21 406



Pharmacy For Sale or Rent

Excellent Pharmacy In Elzawia For Sale Or Rent

Excellent income & excellent price

Please call

Tel: 011 8401578



Pharmacy for sale

Pharmacy for sale in Abou homos-Bhira.

For more details contact 01523935991








Pharmacists_coffee magazine

Electronic Edition 


Emirates to Emirates

   + Add a vacancy





Pharmacist, female, on husband's visa, with MOH licence, required in Sharjah.






Part-time Pharmacist, Indian female, with MOH licence, required for a pharmacy.

Contact 056-6284324 / 06-7422210.




Pharmacist, with MOH licence & experience, required for a pharmacy in Sharjah.

Fax CV to 06-5486200.




Assistant Pharmacist & Pharmacist, with MOH licence, required for a pharmacy in Karama.

Fax CV to: 06-5579002 / E-mail:





Pharmacist, with MOH license, required for a pharmacy in Sharjah.

Send CV to 06-5631490 /





Registered Pharmacist, with MOH & DOH license, required for a pharmacy.

Send CV to 04-3988116.




Assistant Pharmacist, with MOH license, required for a pharmacy.

Send CV to 04-3988116.




A well-reputed pharmacy requires a Pharmacist. To be viewed by employers,

post your CV on




Indian Female, completed B.Pharmacy (Fresher without MOH) & seeks job as pharmacist trainee. Currently in Dubai on Father's sponsorship visa, available to join immediately. E-mail:





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Bayer's Rivaroxaban Submitted for Approval in Japan

Friday, 15 April 2011

Bayer's rivaroxaban (Xarelto®) has been submitted for marketing approval in the prevention of stroke in patients with atrial fibrillation to the Japanese Ministry of Health, Labor and Welfare (MHLW).


Five-year Alemtuzumab Phase 2 Data Shows Large Percentage of MS Patients Remain Free of Clinically-Active Disease

Friday, 15 April 2011

Genzyme Corp., a subsidiary of sanofi-aventis Group (EURONEXT: SAN and NYSE: SNY), reported additional five-year patient data from its completed Phase 2 multiple sclerosis (MS) trial showing that nearly two-thirds of alemtuzumab treated patients remained free of clinically-active disease


Forest Laboratories Completes Acquisition of Clinical Data, Inc.

Thursday, 14 April 2011

Forest Laboratories, Inc. (NYSE: FRX) ("Forest") has successfully completed its acquisition of Clinical Data, Inc. (NASDAQ: CLDA) ("Clinical Data") by means of what is known as a short-form merger under Delaware law.


Nycomed acquires distribution rights to product portfolio in Turkey

Thursday, 14 April 2011

Nycomed has entered into several agreements with various pharmaceutical companies, including Almirall S.A., Anika Therapeutics, Inc., Bionorica AG, CSL Behring and Helsinn Healthcare SA.


Novartis discontinues clinical trial of Tasigna®

Wednesday, 13 April 2011

Novartis is discontinuing a Phase III trial of Tasigna® (nilotinib) for investigational use in the first-line treatment of gastrointestinal stromal tumors (GIST) based on the recommendation of an independent data monitoring committee.


Boehringer Ingelheim maintains sales level/course set for the future: product pipeline well-filled

Tuesday, 12 April 2011

In the business year 2010, Boehringer Ingelheim almost compensated for the anticipated loss of turnover announced in advance last year, nearly achieving the previous year's level.


Pfizer and Medivation Announce Results from Phase 3 HORIZON Trial of Dimebon in Huntington Disease

Tuesday, 12 April 2011

Pfizer Inc (NYSE: PFE) and Medivation, Inc. (NASDAQ: MDVN) announced results from the Phase 3 HORIZON trial of the investigational drug dimebon (latrepirdine*) in patients with Huntington disease. Dimebon did not achieve statistical significance for either of the co-primary endpoints,



































































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Manager's Tips 77)

UNDERSTANDING DELEGATION; Delegation is giving someone (usually a subordinate) the authority to carry out a task. They are accountable for the task, & can make decisions relating to it (within any limits that are set), but the manager keeps the overall responsibility. Remember effectiveness & efficiency?  Well, the most effective managers spend their time doing only the tasks that only they can do & delegate the rest to their subordinates.
As a giver of delegated tasks you must ensure delegation happens properly. Just as significantly, as the recipient of delegated tasks you have the opportunity to 'manage upwards' & suggest improvements to the delegation process & understanding – especially if your boss could use the help.

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Bahgat LinkedIn

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